Profhilo vs Nucleofill vs Seventy Hyal — which skin booster is right for you?

We’re asked this question — Profhilo, Nucleofill or Seventy Hyal — at least once a week. Often, by clients who already have an answer in mind based on what they’ve read on Instagram. Almost as often, the answer they’ve arrived at isn’t quite right for the skin in front of me.

This is the proper comparison: what each one actually does, how they differ in practice, what they cost in London, and — at the end — which one I’d suggest at different starting points.

All three are not the same product

It’s tempting to lump them together because they’re all “injected hydration.” They’re not. The chemistry is genuinely different, and the results play out on different timelines and in different ways.

Profhilo is a high-concentration hyaluronic acid that spreads sideways through the skin after injection. It hydrates broadly and stimulates four key proteins — two types of collagen and two types of elastin. It’s a bio-remodelling treatment first, a hydrator second.

Nucleofill is a polynucleotide gel. Short strands of purified salmon-derived DNA that stimulate skin regeneration and improve elasticity at the cellular level. It’s more focused than Profhilo, and more regenerative.

Seventy Hyal is a hyaluronic-acid booster designed to sit closer to the surface. It hydrates and gives a quick glow without the slow build of Profhilo or the regenerative emphasis of Nucleofill.

Timing and protocol

Profhilo is a two-session protocol four weeks apart. That isn’t a suggestion — the molecule was designed for that pattern and the result really does build between sessions. After two sessions, results last six to eight months, and most clients return for a single maintenance dose twice a year.

Nucleofill is more flexible. Two sessions if you want a glow, three or four if you’re addressing under-eye texture or post-summer damage, spaced two to four weeks apart. Maintenance every four to six months.

Seventy Hyal is the quickest. A single session works for most clients and delivers a noticeable result within seven to ten days. Repeat every four to six months if you like it.

What each treats best

Profhilo for: overall skin quality in the 30s, 40s and beyond. Bounce, firmness, that hard-to-describe difference between skin that “looks tired” and skin that “looks well.” Particularly good on the neck and décolletage, where it gives noticeable firmness within six weeks.

Nucleofill for: tired, post-summer skin. The under-eye area when filler isn’t appropriate (often the case). Mild crepiness around the eyes. Scalp protocols for hair thinning.

Seventy Hyal for: clients in their 20s and early 30s who want a glow without committing to a full bio-remodelling course. Pre-event skin preparation with two to three weeks lead time. A first taste of skin boosters before committing further.

The right question is not “which is best?” — it’s “which is best for the skin I have, today, and what I want from it.”

A word on the “Profhilo myth”

Profhilo is the most-asked-for by name, partly because it has been beautifully marketed for nearly a decade. That doesn’t mean it’s the right starting point for everyone. I see clients in their late twenties who have been told they need Profhilo when what they need is twice-yearly Seventy Hyal and a better moisturiser. I see clients in their fifties for whom Profhilo alone won’t do the job because the changes they want to address are structural, not hydrational.

We use Profhilo a lot. It’s a good product. It’s also a product, not a magic spell.

Costs in London

This varies by clinic and by practitioner experience. At Prive, in May 2026:

• Profhilo — £350 per single session, £650 for the recommended course of two
• Nucleofill — £320 per session
• Seventy Hyal — £290 per session

Maintenance for any of the three is one session every four to six months, which means an annual cost in the £300–800 range depending on which you choose and how often.

What I’d suggest at different starting points

If you’re in your late twenties or early thirties and want to test the water, I’d suggest a single session of Seventy Hyal. You’ll know within a fortnight whether the result is worth pursuing further.

If you’re in your mid-thirties to early fifties and want a meaningful, ongoing investment in your skin’s quality, I’d suggest the full Profhilo protocol — two sessions four weeks apart — and a follow-up at six months.

If your concern is specifically tired-looking under-eyes that don’t suit filler (which is most clients with that concern), or your skin has had a hard summer of sun, I’d suggest a course of Nucleofill — usually three sessions.

If you can’t decide, come in for a consultation. We’ll look at your skin under proper lighting, talk through what you actually want it to do, and pick one. You’ll spend more time deciding here than you will deciding in your own bathroom mirror.

A combined plan, in many cases

The honest truth is that a lot of our long-term clients use more than one. Profhilo annually as the foundation, with a Nucleofill course in early autumn after the summer, and a Seventy Hyal top-up before a particular event. The right combination is the one that fits your skin, your life, and your budget — not the one that’s loudest on social media this month.

The clients who come back disappointed are almost always the ones who chose a product without a plan. A clear plan with the slightly-less-fashionable booster usually beats an aimless plan with the most expensive one.

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If you’d like our recommendation, book a consultation — they’re complimentary, there’s no commitment to treatment, and you’ll leave with a clear sense of what suits your skin.